Effect of SARS-COV-2 on kidney tissue: a narrative review

  • Aldo Flores Gavino Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú. https://orcid.org/0000-0002-0163-7981
  • Ricardo Espinoza Anchaygua Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú. https://orcid.org/0000-0001-5778-6970
  • Percy Herrera Añazco Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú; Servicio de Nefrología, Hospital Nacional Dos de Mayo. Lima, Perú. https://orcid.org/0000-0003-0282-6634
  • Alfonso J. Rodriguez-Morales Grupo de Investigación Salud Pública e Infección, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Grupo de Investigación Biomedicina, Facultad de Medicina, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia. https://orcid.org/0000-0001-9773-2192
Keywords: Histopathology, Pathophysiology, SARS-CoV-2, COVID-19, Acute Kidney Injury, Kidney

Abstract

We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications.  SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin–Angiotensin–Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use.

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Published
2021-05-23
How to Cite
1.
Flores Gavino A, Espinoza Anchaygua R, Herrera Añazco P, Rodriguez-Morales AJ. Effect of SARS-COV-2 on kidney tissue: a narrative review. Acta Med Peru [Internet]. 2021May23 [cited 2024Mar.28];38(1):53-7. Available from: https://amp.cmp.org.pe/index.php/AMP/article/view/1885