Cryptococcal meningitis in a patient with idiopathic CD4+ T lymphopenia

Keywords: Meningitis, Cryptococcal, T-Lymphocytopenia, Idiopathic CD4-Positive Lymphopenia, Immunologic Deficiency Syndromes, HIV, Perú


Infection with the human immunodeficiency virus (HIV) is the main risk factor for developing cryptococcal meningitis. However, there is a poorly known entity, idiopathic CD4+ T-cell lymphopenia, which leads to an unexplainable CD4+ circulating T-cell deficit, predisposing patients to many complications, including infections caused by opportunistic microorganisms. We present the case of a patient with cryptococcal meningitis secondary to idiopathic T-CD4+ lymphopenia, which, as far as we know, is the very first case of its kind reported in Peru. This entity should be considered in patients negative for HIV infection developing non-common infections of the central nervous system, since outcome, management, and prognosis may be different in patients with this condition.


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How to Cite
Esquivel Luna JS, Zelada Ríos LC, Bejarano Ferreyra JH. Cryptococcal meningitis in a patient with idiopathic CD4+ T lymphopenia. Acta Med Peru [Internet]. 2021Aug.23 [cited 2024Jun.25];38(2). Available from: