Genetic mutations that confer resistance to Isoniazid in patients with Tuberculosis in Lima Centro, Perú 2017- 2018

Keywords: Mycobacterium tuberculosis, Tuberculosis, Multidrug-Resistant, Mutation, Isoniazid, Perú

Abstract

This a report of the frequency of KatG and inhA genetic mutations that confer resistance to isoniazid in a sample of 777 patients with resistance to isoniazid. GenoType® MTBDRplus test and conventional sensitivity tests by the agar plate method were used. It was found that 54% presented mutation in the KatG gene, associated with higher resistance to streptomycin 76.6% (p <0.05), rifampicin 66.7% (p <0.05) and ethionamide in 33% (p <0.05). inhA gene mutation has a frequency of 46% and was associated with resistance to ethionamide in 68.1% (p <0.05), rifampicin 47.2% (p <0.05) and streptomycin 33% (p <0.05). In this sample, the presences of mutations that confer resistance to isoniazid was associated with resistance to other antituberculosis drugs.

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Published
2021-08-23
How to Cite
1.
Vargas Ponce K, Trujillo Valencia C, Saravia Ruiz T, Salas López A, Llanos Tejada F. Genetic mutations that confer resistance to Isoniazid in patients with Tuberculosis in Lima Centro, Perú 2017- 2018. Acta Med Peru [Internet]. 2021Aug.23 [cited 2021Sep.21];38(2). Available from: https://amp.cmp.org.pe/index.php/AMP/article/view/1892
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