Efficacy of sodium valproate in the prophylactic treatment of migraine

  • Juan Fernando Lizárraga Luyo Hospital Central Policia Nacional del Perú "Luis N. Sáenz"
  • Pilar Milagros Jara Pinto Médico Cirujano
  • Leónidas E. Unzueta Rozas Médico Cirujano de Cabeza y Cuello
Keywords: valproato de sodio Migraine Disorders, pain, valproic acid, efficacy


Introduction: migraine is a chronic recurrent pain syndrome accompanied by neurological features.

Objectives: evaluate the efficacy of sodium valproate in the migraine prophylactic, measuring pain intensity and frequency.

Material and Methods: prospective, longitudinal, experiemental and randomized in 30 patients, each patient received in the 1st week 1 table/day of 500 mg orally and 2 table/day of 500 mg for the next 7 weeks

Results: 97% reported decreased pain intensity. 97% were in category 3 of frequency of migraine attacks per month 0. during the 1 st month of treatment, it was reduced to 0% and remained during the 2nd month. Conclusions: prophylactic treatment of migraine with sodium valproate causes a decrease in pain intensity and frequency.


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How to Cite
Lizárraga Luyo JF, Jara Pinto PM, Unzueta Rozas LE. Efficacy of sodium valproate in the prophylactic treatment of migraine. Acta Med Peru [Internet]. 2012Mar.28 [cited 2024May24];29(1):14-6. Available from: https://amp.cmp.org.pe/index.php/AMP/article/view/1137